Fig. 3

CTHRC1 expression was potentially associated with tumor angiogenesis markers in LUAD. a Patients with high CTHRC1 expression had a higher MVD count (mean: 23.9 vs. 28.4; **P < 0.01). b GSEA for angiogenesis between the high-CTHRC1 group and the low-CTHRC1 group in LUAD. c Scatter plot showing the correlation log fold change between CTHRC1 and VEGF in TCGA patients with LUAD (n = 514; r = 0.537, P = 0.002). d GSEA results of angiogenesis gene sets for the high-CTHRC1 expression group in TCGA patients with LUAD. e WB analysis of CTHRC1 and VEGFA expression in each of the primary LUAD tissue (T) and corresponding non-cancerous tissue (N). GSEA, Gene Set Enrichment Analysis; ES, enrichment score; NES, normalized enrichment score; NOM P-value, normalized P-value; TCGA, the Cancer Genome Atlas; WB, western blotting; CTHRC1, Collagen triple helix repeat containing 1; VEGFA, vascular endothelial growth factor A; LUAD, lung adenocarcinoma