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Fig. 1 | Cancer Cell International

Fig. 1

From: S-15 in combination of Akt inhibitor promotes the expansion of CD45RACCR7+ tumor infiltrating lymphocytes with high cytotoxic potential and downregulating PD-1+Tim-3+ cells as well as regulatory T cells

Fig. 1

Efficiency of Tils expansion via IL-2, IL-2/S-15, IL-2/Akti and IL-2/S-15/Akti. a Growth profiles of Tils from HCC patients during the 25-day initial culture period. Data represent the mean ± SEM of six independent experiments. b The total number of Tils in the IL-2, IL-2/S-15, IL-2/Akti and IL-2/S-15/Akti-expanded cultures is depicted for 6 HCC patients. Growth profiles of CD8+ T cells (c), CD4+ T cells (d), CD8 CD4 T cells (e) within the CD3+ population during the 25-day initial culture period. Percentages of CD8+ T cells, CD4+ T cells, CD8 CD4 T cells within the CD3+ population at day 25 were shown respectively in f, g and h. Statistical significance was analyzed by repeated measures ANOVA. *P < 0.05, **P < 0.01, ***P < 0.001

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