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Fig. 2 | Cancer Cell International

Fig. 2

From: Up-regulation of circ_LARP4 suppresses cell proliferation and migration in ovarian cancer by regulating miR-513b-5p/LARP4 axis

Fig. 2

Up-regulating circ_LARP4 hampers cell proliferation and migration of OC cell lines. a The qRT-PCR analysis was employed to determine the expression of circ_LARP4 with increasing circ_LARP4. b Cell counting kit-8 (CCK-8) assay was applied to detect cell viability under circ_LARP4 overexpression (OE-circ_LARP4). c Colony formation assay was carried out to estimate cell proliferation ability with OE-circ_LARP4. d Implementing western blot assay to detect apoptosis related protein level (Bax, Bcl-2, Cleaved caspase-3, Total caspase-3, Cleaved caspase-9 and Total caspase-9) under the condition of OE-circ_LARP4. e, f Transwell assay was conducted to test cell invasion and migration capacities. g Invasion and migration related protein levels (MMP2, MMP7 and MMP9) were measure by Western blot assay. All data were performed as the mean ± SD. **P < 0.01

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Cancer Cell International

ISSN: 1475-2867

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