Fig. 7
From: UBQLN4 promotes progression of HCC via activating wnt-β-catenin pathway and is regulated by miR-370
UBQLN4 was targeting regulated by miR-370 in HCC cells. a Expression of UBQLN4 was detected under treatment of selected miRNA mimics in HCC cells. b Relative luciferase activity between UBQLN4 wild type and mutant type based on a dual-luciferase reporter assay. Values represent the mean ± SD (n = 5, each). c miR-370 could be specific complementary pairing with 3′UTR sequence of UBQLN4. d, e Protein and mRNA change of UBQLN4 in HCC cells under treatment of miR-370 mimics, inhibitor and negative control. f Relationship between UBQLN4 expression and miR-370 expression in HCC tissues. *p < 0.05, **p < 0.01