UBQLN4 promotes progression of HCC via activating wnt-β-catenin pathway and is regulated by miR-370

Table 1 Correlation of clinico-pathological features with UBQLN4 expression in ZZU HCC cohort

Variables	Clinicopathological features	UBQLN4 expression		p-value
Variables	Clinicopathological features	Low expression (n = 162)	High expression (n = 179)	p-value
Age (years)	≤ 50	54	72	0.188
Age (years)	> 50	108	107
Gender	Male	125	140	0.816
Gender	Female	37	39
Pathogenesis	Virus	116	139	0.199
Pathogenesis	Others	46	40
Cirrhosis	Absent	147	168	0.279
Cirrhosis	Present	15	11
Tumor size (cm)	≤ 5	93	79	0.014
Tumor size (cm)	> 5	100	69
Vascular invasion	Absent	138	131	0.006
Vascular invasion	Present	24	48
TNM stage	Stage I and II	135	128	0.009
TNM stage	Stage III and IV	27	51
AFP	≤ 20	87	79	0.077
AFP	> 20	75	100
Tumor multiplicity	Single	87	72	0.012
Tumor multiplicity	Multiple	75	107
State	Live	120	110	0.013
State	Dead	42	69

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