Table 1 Gene ontology enrichment analysis of MeDEGs
From: Comprehensive analysis of DNA methylation and gene expression profiles in cholangiocarcinoma
Category | Term ID | Term description | Count | False discovery rate |
|---|---|---|---|---|
Hypermethylated downregulated genes | ||||
 BP_FAT | GO:0019752 | Carboxylic acid metabolic process | 22 | 5.98E−07 |
 BP_FAT | GO:0071466 | Cellular response to xenobiotic stimulus | 9 | 8.39E−05 |
 BP_FAT | GO:0006805 | Xenobiotic metabolic process | 7 | 8.00E−04 |
 BP_FAT | GO:0042737 | Drug catabolic process | 7 | 8.00E−04 |
 BP_FAT | GO:0045861 | Negative regulation of proteolysis | 11 | 8.00E−04 |
 BP_FAT | GO:0006953 | Acute-phase response | 5 | 1.30E−03 |
 BP_FAT | GO:0010951 | Negative regulation of endopeptidase activity | 9 | 1.30E−03 |
 BP_FAT | GO:0032787 | Monocarboxylic acid metabolic process | 12 | 1.30E−03 |
 BP_FAT | GO:0001676 | Long-chain fatty acid metabolic process | 6 | 3.30E−03 |
 BP_FAT | GO:0044281 | Small molecule metabolic process | 23 | 3.30E−03 |
 CC_FAT | GO:0005576 | Extracellular region | 38 | 2.40E−08 |
 CC_FAT | GO:0005615 | Extracellular space | 25 | 2.40E−08 |
 CC_FAT | GO:0044421 | Extracellular region part | 28 | 2.40E−08 |
 CC_FAT | GO:0044432 | Endoplasmic reticulum part | 19 | 1.30E−03 |
 MF_FAT | GO:0004866 | Endopeptidase inhibitor activity | 9 | 1.20E−04 |
 MF_FAT | GO:0004857 | Enzyme inhibitor activity | 11 | 4.20E−04 |
 MF_FAT | GO:0004867 | Serine-type endopeptidase inhibitor activity | 6 | 7.80E−04 |
 MF_FAT | GO:0008395 | Steroid hydroxylase activity | 4 | 1.90E−03 |
 MF_FAT | GO:0015370 | Solute:sodium symporter activity | 5 | 3.60E−03 |
 MF_FAT | GO:0016491 | Oxidoreductase activity | 13 | 3.60E−03 |
Hypomethylated upregulated genes | ||||
 BP_FAT | GO:0007049 | Cell cycle | 20 | 3.20E−03 |
 BP_FAT | GO:0000280 | Nuclear division | 8 | 1.61E−02 |
 BP_FAT | GO:0010948 | Negative regulation of cell cycle process | 8 | 1.61E−02 |
 BP_FAT | GO:0022402 | Cell cycle process | 15 | 1.61E−02 |
 BP_FAT | GO:0045839 | Negative regulation of mitotic nuclear division | 4 | 1.61E−02 |
 BP_FAT | GO:0045930 | Negative regulation of mitotic cell cycle | 8 | 1.61E−02 |
 BP_FAT | GO:0048519 | Negative regulation of biological process | 41 | 1.61E−02 |
 BP_FAT | GO:0051726 | Regulation of cell cycle | 17 | 1.61E−02 |
 BP_FAT | GO:1903047 | Mitotic cell cycle process | 12 | 1.61E−02 |
 BP_FAT | GO:0007093 | Mitotic cell cycle checkpoint | 6 | 1.66E−02 |
 BP_FAT | GO:0051716 | Cellular response to stimulus | 46 | 3.22E−02 |
 BP_FAT | GO:0007568 | Aging | 7 | 3.23E−02 |
 BP_FAT | GO:0031577 | Spindle checkpoint | 3 | 3.23E−02 |
 BP_FAT | GO:0051302 | Regulation of cell division | 6 | 3.23E−02 |
 BP_FAT | GO:2000816 | Negative regulation of mitotic sister chromatid separation | 3 | 3.23E−02 |
 BP_FAT | GO:0007010 | Cytoskeleton organization | 13 | 3.36E−02 |
 BP_FAT | GO:0007051 | Spindle organization | 5 | 3.36E−02 |
 BP_FAT | GO:0007052 | Mitotic spindle organization | 4 | 3.36E−02 |
 BP_FAT | GO:0007346 | Regulation of mitotic cell cycle | 10 | 3.36E−02 |
 BP_FAT | GO:0009888 | Tissue development | 18 | 3.36E−02 |