Fig. 8

Copy number analysis of parental and their corresponding xenograft tumors using whole-exome sequencing. a In the CNV analysis plot, the pattern of CNV of the parental gliomas of patient 20180521 were generally replicated by grafted tumors through the generations and the recurrence and aggressiveness. b Principal component analysis (PCA) showed that the tumors from the same patient and their matched PDXs clustered together. c Genomic gain is indicated in green and genomic loss is indicated in blue over all chromosomes of the primary tumor of patient 20180521, the corresponding PDXs (P1 to P3) and the distance growth tumors