Long non-coding RNA GAS5 accelerates oxidative stress in melanoma cells by rescuing EZH2-mediated CDKN1C downregulation

Table 3 Correlation analysis between the lncRNA GAS5 expression and the clinicopathological features of melanoma patients

Clinicopathological features	Cases (n = 75)	Expression of lncRNA GAS5		p value
Clinicopathological features	Cases (n = 75)	Low expression (n = 58, 77.33%)	High expression (n = 17, 22.67%)	p value
Gender
Male	28	21 (75)	7 (25)	0.710
Female	47	37 (78.72)	10 (21.28)	0.710
Age
≤ 65 years	49	37 (75.51)	12 (24.49)	0.373
> 65 years	26	21 (80.77)	5 (19.23)	0.373
Breslow thickness
≤ 4 mm	18	6 (33.33)	12 (66.67)	0.001
> 4 mm	57	52 (91.23)	5 (8.77)	0.001
Ulceration
No	22	7 (31.92)	15 (68.18)	0.001
Yes	53	51 (96.23)	2 (3.77)	0.001
Lymph node metastasis
Negative	24	12 (42.86)	16 (57.14)	0.001
Positive	51	45 (97.83)	1 (2.17)	0.001
TNM staging
I	19	4 (21.05)	15 (78.95)	0.0001
II/III	56	54 (96.43)	2 (3.57)	0.0001

Data were measurement data, expressed by mean ± standard deviation. Data comparison was analyzed by Chi square test. p < 0.05 indicates significant difference

ISSN: 1475-2867