Fig. 1
From: The histone demethylase JMJD2A promotes glioma cell growth via targeting Akt-mTOR signaling
JMJD2A is up-regulated in human glioma. aJMJD2A mRNA level in normal control brain tissues (n = 7) and human glioma tissues (n = 19). **p < 0.01. b JMJD2A, H3K9me3, H3K36me3 protein level in normal control brain tissues (n = 4) and human glioma tissues (n = 4). GAPDH and histone H3 were loading controls. c Quantitative results of the JMJD2A protein level in (b). *p < 0.05. n = 4 in each group. d Quantitative results of H3K9me3 protein level in (b). *p < 0.05. n = 4 in each group. e Quantitative results of H3K36me3 protein level in (b). *p < 0.05. n = 4 in each group. f JMJD2A mRNA level in human normal astrocyte cells (NHA) and glioma cell lines (T98G, U251, U87MG, A172, and CCF-STTG1). *p < 0.05, ** p < 0.01 vs. NHA. g Expression of JMJD2A in glioma and control normal tissues analyzed with GEPIA. ***p < 0.001. h Survival analysis (Kaplan–Meier curve) of high JMJD2A expression (top 25%) and low JMJD2A expression (bottom 25%) glioma patients. Log-rank p = 1.7E–5