Fig. 2

Arginase inhibits cytoskeletal reorganization needed for cell migration. Upon the production of nitric oxide from l-arginine, FAK gets phosphorylated activating Cdc42, Rac1 and RhoA by replacing GDP with GTP. Collectively, RhoGTPases lead to the regulation of the actin cytoskeleton and the formation of actin structures and dynamics needed for cell migration, such as filopodia and lamellipodia formation and focal adhesion dynamics. These are required for cancer cell migration, hence arginase leads to the inhibition of cancer cell migration through the inhibition of these events