Fig. 1

CRNDE significantly promotes cell proliferation through mediating multiple signaling pathways and various target genes. Among them, the most important pathways are Wnt/β-catenin, PI3K/AKT, NF-κB/AKT and Ras/MAPK signaling pathway, and the most relevant target microRNAs including miR-181a-5p, miR-136-5p, miR-217, miR-384, miR-203, miR-186, miR-205, miR-145 and miR-451. Moreover, the accumulation of TP53 is correlated with decreased expression of CRNDE, while the accumulation of hnRNPUL2 in the cytoplasm increases the stability of CRNDE