Fig. 4

HE4 overexpression decreased Capan-1 cell sensitivity to Pac-caused inhibition of cell viability. MTT assays were performed at 24, 48, 72, and 96 h time points. a Results of the four experimental groups at different time points. b D/C and B/A values were plotted against time. Note the separation of the two curves at 72 and 96 h time points. c The X values increased significantly over the control after 48 h of Pac treatment. *p < 0.05; ** P < 0.01