Fig. 5

HE4 overexpression decreased the Capan-1 cell sensitivity to Pac-caused inhibition of DNA synthesis. a Representative results of BrdU incorporation assay in the four groups of control, HE4, Pac, and HE4 + Pac. b BrdU positivity was calculated for each experimental group. c B/A and D/C values were significantly increased with HE4 overexpression. The higher than one X value suggested that HE4 overexpression decreased cell sensitivity to paclitaxel, and the HE4 overexpression and paclitaxel effects were interactive. *p < 0.05; ** p < 0.01