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Fig. 1 | Cancer Cell International

Fig. 1

From: N-alkylisatin-based microtubule destabilizers bind to the colchicine site on tubulin and retain efficacy in drug resistant acute lymphoblastic leukemia cell lines with less in vitro neurotoxicity

Fig. 1

Chemical Structures of the three N-alkylisatin derivatives. Derivation of the 5,7-dibromoisatin scaffold (blue) led to the development of potent antimitotic N-alkylated analogues: 5,7-dibromo-N-(p-hydroxymethylbenzyl)isatin (HMB-isatin), 5,7-dibromo-N-(1H-indol-4-ylmethyl)isatin (I4M-isatin) and 5,7-dibromo-N-(naphthalene-2-ylmethyl)isatin (N2M-isatin)

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Cancer Cell International

ISSN: 1475-2867

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