Table 1 IC50 (µM) values and fold decrease in drug sensitivity (RI) of parental (CEM) versus resistant (CEM-VCR R and CEM/2ME2 28.8R) human acute lymphoblastic leukemia cell lines treated with microtubule targeting agents
IC50 (µM) ± SDa | Resistance Index (RI)b | ||||
|---|---|---|---|---|---|
Compound | CEM | CEM-VCR R | CEM/2ME2-28.8R | CEM-VCR R:CEM | CEM/2ME2-28.8 R:CEM |
Vincristine | 0.08 (± 0.05) | 8.11 (± 1.62) | 0.41 (± 0.19) | 101.4 < 0.05 | 5.1 > 0.05 |
Vinblastine | 0.13 (± 0.06) | 1.12 (± 0.16) | 0.39 (± 0.13) | 8.6 < 0.05 | 3.0 > 0.05 |
2-Methoxy-estradiol | 0.08 (± 0.04) | 4.07 (± 1.34) | 8.52 (± 1.38) | 50.9 < 0.05 | 106.5 < 0.05 |
Colchicine | 0.32 (± 0.21) | 1.01(± 0.36) | 0.56 (± 0.19) | 3.2 < 0.05 | 1.8 > 0.05 |
Paclitaxel | 0.15 (± 0.09) | 1.11 (± 0.36) | 0.25 (± 0.12) | 7.4 < 0.05 | 1.7 > 0.05 |
HMB-isatin | 1.02 (± 0.32) | 1.07 (± 0.37) | 1.29 (± 0.41) | 1.0 > 0.05 | 1.3 > 0.05 |
I4M-isatin | 1.07 (± 0.44) | 1.26 (± 0.19) | 1.16 (± 0.46) | 1.2 > 0.05 | 1.1> 0.05 |
N2M-isatin | 0.36 (± 0.19) | 0.49 (± 0.36) | 0.46 (± 0.32) | 1.4 > 0.05 | 1.3 > 0.05 |