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Fig. 5 | Cancer Cell International

Fig. 5

From: Ubiquitin ligase CHAF1B induces cisplatin resistance in lung adenocarcinoma by promoting NCOR2 degradation

Fig. 5

Animal experiments verify the function of CHAF1B and NCOR2. a The inhibition effect of cisplatin on the volume of transplanted tumors after A549/DDP knockdown of CHAF1B was significantly greater than that of the control group. b WB confirmed that the expression of CHAF1B was up-regulated in A549/DDP and NCOR2 was up-regulated in CHAF1B knockdown group. c The expression of Ki-67 was significantly lower in A549/DDP after knocking down CHAF1B than in the control group. d The TUNEL showed that apoptosis was significantly higher in A549/DDP after knocking down CHAF1B than that in the control group. Bars indicated standard deviation, *p < 0.05, ***p < 0.001, ****p < 0.0001. DDP: IC25 concentration of cisplatin to A549/DDP

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Cancer Cell International

ISSN: 1475-2867

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