Fig. 8

SNHG16 deletion contributes to cisplatin-mediated inhibition on tumor growth in vivo. SK-N-AS-R resistant cells stably infected with lenti-sh-SNHG16 or lenti-sh-NC were subcutaneously inoculated into the flanks of the nude mice, followed by intravenously injection with cisplatin (3 mg/kg) every 7 days. a Tumor volume was calculated every 7 days. b Mice were killed on day 28 after infection, and then tumor masses were excised and weighed. c–e The expressions of SNHG16, miR-338-3p, and PLK4 in excised tumor masses were determined using qRT-PCR and western blot, respectively (N = 3). N means that triplicate individual experiments were performed, and the average was taken. *P < 0.05