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Fig. 8 | Cancer Cell International

Fig. 8

From: SNHG16 promotes tumorigenesis and cisplatin resistance by regulating miR-338-3p/PLK4 pathway in neuroblastoma cells

Fig. 8

SNHG16 deletion contributes to cisplatin-mediated inhibition on tumor growth in vivo. SK-N-AS-R resistant cells stably infected with lenti-sh-SNHG16 or lenti-sh-NC were subcutaneously inoculated into the flanks of the nude mice, followed by intravenously injection with cisplatin (3 mg/kg) every 7 days. a Tumor volume was calculated every 7 days. b Mice were killed on day 28 after infection, and then tumor masses were excised and weighed. ce The expressions of SNHG16, miR-338-3p, and PLK4 in excised tumor masses were determined using qRT-PCR and western blot, respectively (N = 3). N means that triplicate individual experiments were performed, and the average was taken. *P < 0.05

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