Table 4 Univariate and multivariate Cox regression analysis of TCGA-LIHC patients

Risk score

2.948 (1.752–4.961)

0.000

2.349 (1.289–4.279)

0.005

Age (years)

  < 60

1

1

  ≥ 60

1.535 (0.923–2.552)

0.099

1.593 (0.935–2.714)

0.086

Sex

 Female

1

 Male

0.673 (0.405–1.119)

0.127

1.023 (0.588–1.779)

0.936

BMI (kg/m²)

 < 25

1

–

–

  ≥ 25

1.214 (0.738–1.999)

0.445

–

–

G stage

 G1 + G2

1

1

 G3 + G4

1.536 (0.930–2.536)

0.094

1.364 (0.791–2.352)

0.265

Residual tumor

 R0

1

–

–

 Non-R0

1.328 (0.413–4.278)

0.634

–

–

AJCC stage

 I + II

1

1

 III + IV

2.271 (1.321–3.904)

0.003

2.219 (1.215–3.734)

0.008

Vascular invasion

 No

1

1

 Yes

1.760 (1.048–2.958)

0.033

1.266 (0.730–2.196)

0.401

AFP (ng/ml)

  < 300

1

–

–

  ≥ 300

1.171 (0.668–2.054)

0.581

–

–