Fig. 8
The methylation status of HSD17B6 promoter is dependent on E2F6. a, b Correlation of HSD17B6 expression with E2F6 expression in TCGA-LIHC dataset. c E2F6 binds to the promoter region of HSD17B6. Re-analysis of six different E2F6 ChIP-seq data available in CistromeDB platform. E2F6 chromatin immunoprecipitation was performed in four different human cancer-derived cell lines: A549 (lung carcinoma), H1 (embryonic stem cell), HeLa-S3 (cervical adenocarcinoma) and K562 (chronic myelogenous leukemia, including 3 ChIP-seq datasets from different research), and the presence of DNA peaks was evaluated in HSD17B6 promoter regions