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Fig. 5 | Cancer Cell International

Fig. 5

From: ZKSCAN3 drives tumor metastasis via integrin β4/FAK/AKT mediated epithelial–mesenchymal transition in hepatocellular carcinoma

Fig. 5

AKT phosphorylation acts downstream of ZKSCAN3 to promote migration and invasion of HCC cells. a ZKSCAN3 overexpression promoted AKT phosphorylation while ZKSCAN3 knockdown inhibited AKT phosphorylation. b ITGB4 knockdown inhibited AKT phosphorylation in HCCLM3 cells. c, d AKT phosphorylation inhibitor MK2206 was used in ZKSCAN3-overexpressing cells. Transwell assay for migration and invasion (c) and western blot (d) for EMT markers were performed. *P < 0.05

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Cancer Cell International

ISSN: 1475-2867

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