Fig. 4

Effects of SFRP1 on cell migration and invasion. Cell migration by wound healing assay, VCaP cells were treated for 96 h, increased migration was observed but was not significant in this assay (a, b). Cell invasion analyzed by xCELLigence system, VCaP cells were treated for 72 h and invasion was monitored in real-time every 15 min, ****p ≤ 0.0001 (c). Expression of LEF-1 in VCaP cells, **p ≤ 0.0045 (d). Cells were treated for 24 h with DHT and SFRP1 (0.01 nM each)