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Table 1 SNPs of high and moderate predicted impact in CAMA-1_ribociclib_resistant cells compared to parental CAMA-1 cells

From: Exploiting collateral sensitivity controls growth of mixed culture of sensitive and resistant cells and decreases selection for resistant cells in a cell line model

Gene symbol Predicted SNP impact Predicted SNP effect Detected mutation Gene’s implication in cancer prognosis/progression
MIA3 High Stop gained c.2335A>T p.Lys779*  
BTLA High Stop gained c.94G>T p.Glu32*  
SAMD9 High Stop gained c.2827G>T p.Gly943*  
ARMCX2 High Stop gained c.1055C>A p.Ser352*  
WDFY3 High Stop gained c.7504C>T p.Gln2502*  
SEMA6A High Stop gained c.270T>A p.Tyr90* Benign prognostic factor in glioblastoma [53]
ALDH5A1 High Structural interaction variant c.844T>C p.Phe282Leu Benign prognostic factor in high-grade serous ovarian carcinoma [54]
ARHGDIA High Structural interaction variant c.573C>A p.Ser191Ser Benign prognostic factor in glioma [55]
MAPKBP1 High Stop gained c.3268G>T p.Glu1090*  
SORCS1 Moderate Missense variant c.2303G>A p.Gly768Glu  
RAG1 Moderate Missense variant c.2023C>A p.Leu675Met  
NEUROD4 Moderate Missense variant c.204G>T p.Lys68Asn  
NALCN Moderate Missense variant c.2091T>G p.Ile697Met Somatic mutations in pancreatic ductal adenocarcinomas [64]
AHNAK2 Moderate Missense variant c.12994G>A p.Val4332Met Correlates with poor prognosis in pancreatic ductal adenocarcinomas [65]
MYO9A Moderate Missense variant c.4708G>C p.Glu1570Gln  
CHD2 Moderate Missense variant c.595C>T p.Arg199Cys  
CNTNAP1 Moderate Missense variant c.2109C>G p.Phe703Leu  
NLRP5 Moderate Missense variant c.2448G>A p.Met816Ile  
HEATR5B Moderate Missense variant c.307G>T p.Asp103Tyr  
SPTBN1 Moderate Missense variant c.5222G>T p.Arg1741Leu  
TTC3 Moderate Missense variant c.3788G>C p.Arg1263Thr  
ZNF502 Moderate Missense variant c.503C>T p.Ser168Leu  
CRYBG3 Moderate Missense variant c.1753A>G p.Lys585Glu  
BMP3 Moderate Missense variant c.845C>A p.Ser282Tyr  
TREML2 Moderate Missense variant c.496A>C p.Met166Leu  
DPYD Moderate Missense variant c.384G>T p.Met128Ile  
RASAL2 Moderate Missense variant c.199C>T p.Arg67Trp  
CFAP46 Moderate Missense variant c.1333G>T p.Ala445Ser  
CEP83 Moderate Missense variant c.380A>G p.Glu127Gly  
TSPOAP1 Moderate Missense variant c.3004C>A p.Pro1002Thr  
ZNF761 Moderate Missense variant c.1492G>C p.Glu498Gln  
PAXIP1 Moderate Missense variant c.2004A>T p.Arg668Ser  
RP1 Moderate Missense variant c.5123C>A p.Ala1708Asp Somatic mutations in intramedullary spinal cord ependimomas [66]
NCOA2 Moderate Missense variant c.3320G>T p.Ser1107Ile Frequently amplified in breast cancer [67]
GLYR1 Moderate Missense variant c.1336G>C p.Ala446Pro  
DNAAF4 Moderate Missense variant c.572A>G p.Glu191Gly  
CYP3A43 Moderate Missense variant c.1154T>C p.Leu385Ser  
LRP4 Moderate Missense variant c.4798C>T p.Leu1600Phe  
F11 Moderate Missense variant c.1654C>A p.His552Asn  
CCDC166 Moderate Missense variant c.67G>C p.Ala23Pro  
ANKRD22 Moderate Missense variant c.1253G>A p.Arg418Gln Correlates with relapse and short overall survival in non-small cell lung cancer [68]
REM1 Moderate Missense variant c.188C>T p.Pro63Leu  
PCSK1 Moderate Missense variant c.1270C>G p.Pro424Ala