Table 1 SNPs of high and moderate predicted impact in CAMA-1_ribociclib_resistant cells compared to parental CAMA-1 cells

MIA3

High

Stop gained

c.2335A>T

p.Lys779*

BTLA

High

Stop gained

c.94G>T

p.Glu32*

SAMD9

High

Stop gained

c.2827G>T

p.Gly943*

ARMCX2

High

Stop gained

c.1055C>A

p.Ser352*

WDFY3

High

Stop gained

c.7504C>T

p.Gln2502*

SEMA6A

High

Stop gained

c.270T>A

p.Tyr90*

Benign prognostic factor in glioblastoma [53]

ALDH5A1

High

Structural interaction variant

c.844T>C

p.Phe282Leu

Benign prognostic factor in high-grade serous ovarian carcinoma [54]

ARHGDIA

High

Structural interaction variant

c.573C>A

p.Ser191Ser

Benign prognostic factor in glioma [55]

MAPKBP1

High

Stop gained

c.3268G>T

p.Glu1090*

SORCS1

Moderate

Missense variant

c.2303G>A

p.Gly768Glu

RAG1

Moderate

Missense variant

c.2023C>A

p.Leu675Met

NEUROD4

Moderate

Missense variant

c.204G>T

p.Lys68Asn

NALCN

Moderate

Missense variant

c.2091T>G

p.Ile697Met

Somatic mutations in pancreatic ductal adenocarcinomas [64]

AHNAK2

Moderate

Missense variant

c.12994G>A

p.Val4332Met

Correlates with poor prognosis in pancreatic ductal adenocarcinomas [65]

MYO9A

Moderate

Missense variant

c.4708G>C

p.Glu1570Gln

CHD2

Moderate

Missense variant

c.595C>T

p.Arg199Cys

CNTNAP1

Moderate

Missense variant

c.2109C>G

p.Phe703Leu

NLRP5

Moderate

Missense variant

c.2448G>A

p.Met816Ile

HEATR5B

Moderate

Missense variant

c.307G>T

p.Asp103Tyr

SPTBN1

Moderate

Missense variant

c.5222G>T

p.Arg1741Leu

TTC3

Moderate

Missense variant

c.3788G>C

p.Arg1263Thr

ZNF502

Moderate

Missense variant

c.503C>T

p.Ser168Leu

CRYBG3

Moderate

Missense variant

c.1753A>G

p.Lys585Glu

BMP3

Moderate

Missense variant

c.845C>A

p.Ser282Tyr

TREML2

Moderate

Missense variant

c.496A>C

p.Met166Leu

DPYD

Moderate

Missense variant

c.384G>T

p.Met128Ile

RASAL2

Moderate

Missense variant

c.199C>T

p.Arg67Trp

CFAP46

Moderate

Missense variant

c.1333G>T

p.Ala445Ser

CEP83

Moderate

Missense variant

c.380A>G

p.Glu127Gly

TSPOAP1

Moderate

Missense variant

c.3004C>A

p.Pro1002Thr

ZNF761

Moderate

Missense variant

c.1492G>C

p.Glu498Gln

PAXIP1

Moderate

Missense variant

c.2004A>T

p.Arg668Ser

RP1

Moderate

Missense variant

c.5123C>A

p.Ala1708Asp

Somatic mutations in intramedullary spinal cord ependimomas [66]

NCOA2

Moderate

Missense variant

c.3320G>T

p.Ser1107Ile

Frequently amplified in breast cancer [67]

GLYR1

Moderate

Missense variant

c.1336G>C

p.Ala446Pro

DNAAF4

Moderate

Missense variant

c.572A>G

p.Glu191Gly

CYP3A43

Moderate

Missense variant

c.1154T>C

p.Leu385Ser

LRP4

Moderate

Missense variant

c.4798C>T

p.Leu1600Phe

F11

Moderate

Missense variant

c.1654C>A

p.His552Asn

CCDC166

Moderate

Missense variant

c.67G>C

p.Ala23Pro

ANKRD22

Moderate

Missense variant

c.1253G>A

p.Arg418Gln

Correlates with relapse and short overall survival in non-small cell lung cancer [68]

REM1

Moderate

Missense variant

c.188C>T

p.Pro63Leu

PCSK1

Moderate

Missense variant

c.1270C>G

p.Pro424Ala