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Fig. 5 | Cancer Cell International

Fig. 5

From: Arsenic trioxide potentiates Gilteritinib-induced apoptosis in FLT3-ITD positive leukemic cells via IRE1a-JNK-mediated endoplasmic reticulum stress

Fig. 5

Modulation of downstream targets of FLT3 activation by Gilteritinib plus ATO treatment in MV4-11 cells. af MV4-11 cells were treated with Gilteritinib (2.5 nM) and/or ATO (0.5 µM) for 48 h and protein levels of P-STAT5, STAT5, P-AKT, AKT, P-ERK and ERK were determined by western blot. DMSO treated cells served as a control. Data are shown as mean ± SD for three separate experiments, ***P < 0.001. P-STAT5 phosphorylated-STAT5, P-AKT phosphorylated-AKT, P-ERK phosphorylated-ERK

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