Fig. 9

Targeting endoplasmic reticulum stress to cooperate with Gilteritinib promotes apoptosis of FLT3-ITD-mutated cells. a–d MV4-11 and MOLM13 cells were treated with Gilteritinib (2.5 nM) and/or tunicamycin (TM, 0.2 µM) for 24 h and cell apoptosis was detected using flow cytometry. Data are shown as mean ± SD. *P < 0.05, **P < 0.01. e–h Expression of BAX and BCL-2 in MV4-11 and MOLM13 cells was detected by western blot following 24 h treatment with Gilteritinib (2.5 nM) and/or TM (0.2 µM). Data are shown as mean ± SD. *P < 0.05, **P < 0.01