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Table 3 Correlation of clinicopathological characteristics with HPV presence

From: Co-presence of human papillomaviruses and Epstein–Barr virus is linked with advanced tumor stage: a tissue microarray study in head and neck cancer patients

Degree of differentiation HPV (E6) positive (%) HPV (E6) negative (%) p-value
Tumor grade
 Well-differentiated 6 (8.6) 9 (13) p = 0.02*
 Moderately-differentiated 23 (33.3) 20 (28.9)
 Poorly-differentiated 10 (14.4) 1 (1.4)
 Total 39 (56.5) 30 (43.4)
Tumor Stage (pT)
 pT1 3 (4.4) 14 (20.8) p < 0.001*
 pT2 10 (14.9) 12 (17.9)
 pT3 13 (19.4) 2 (2.9)
 pT4 10 (14.9) 3 (4.4)
 Total 36 (53.7) 31 (46.2)
pN Stage
 pN0 11 (29.7) 8 (21.6) p = 0.045*
 pN1 8 (21.6) 2 (5.4)
 pN2 7 (18.9) 1 (2.7)
 Total 26 (70.2) 11 (29.7)
  1. *Significant p-values