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Table 5 Summary of differential metabolites between OSC and OSC-IC50

From: Untargeted LC–MS/MS analysis reveals metabolomics feature of osteosarcoma stem cell response to methotrexate

 Metabolite143BMG63
VIPP valueFCVIPP valueFC
Amino acidLysyl-Glycine2.591.30 × 10−070.052.305.17 × 10−090.30
Diethanolamine1.027.65 × 10−070.253.805.46 × 10−050.05
Prolyl-Valine2.021.56 × 10−090.061.636.52 × 10−080.34
Alanyl-Isoleucine1.445.13 × 10−110.051.241.38 × 10−090.27
l-Proline1.213.23 × 10−060.071.418.93 × 10−050.20
L-prolyl-l-phenylalanine1.852.95 × 10−090.121.534.61 × 10−060.52
Phenylalanyl-Alanine7.184.58 × 10−130.046.473.25 × 10−110.25
Leucyl-Arginine1.091.98 × 10−090.11.567.75 × 10−090.16
Isoleucyl-Tyrosine2.716.79 × 10−110.092.973.73 × 10−120.19
Phenylalanyl-Glutamate2.287.34 × 10−100.11.792.04 × 10−110.25
S-Methyl-5′-thioadenosine1.993.52 × 10−061.291.198.85 × 10−071.37
Ornithine1.072.35 × 10−090.071.421.60 × 10−090.10
Valyl-Tryptophan1.856.98 × 10−070.052.623.05 × 10−120.06
Alpha-N-Phenylacetyl-l-glutamine1.371.74 × 10−090.051.621.24 × 10−130.08
Tyrosyl-Serine1.568.97 × 10−100.081.351.11 × 10−120.20
Phenylalanylphenylalanine2.621.05 × 10−40.143.691.03 × 10−080.17
Isoleucyl-Tryptophan1.785.36 × 10−40.122.721.02 × 10−070.10
Phenylalanyl-Tryptophan1.595.23 × 10−130.061.241.35 × 10−050.39
L-Targinine1.704.56 × 10−060.041.431.90 × 10−060.05
Methionyl-Valine1.142.71 × 10−050.121.036.06 × 10−050.18
Valyl-Methionine1.721.38 × 10−100.031.841.56 × 10−090.04
Lysyl-Threonine1.221.35 × 10−070.091.074.67 × 10-080.16
Leucyl-Glutamine1.095.00 × 10−070.11.991.60 × 10−080.02
l-Leucine1.334.13 × 10−053.282.053.10 × 10−073.22
Pantothenate1.561.64 × 10−050.675.047.40 × 10−110.26
Glutathione disulfide1.415.28 × 10−051.232.374.21 × 10−1315.32
Harman7.918.60 × 10−122.447.025.15 × 10−144.09
7,8-Dihydrobiopterin1.065.80 × 10−40.262.317.12 × 10−120.08
Fatty acidErucic acid1.553.44 × 10−0721.732.94 × 10−116.93
Erucamide13.401.33 × 10−072.2514.234.21 × 10−109.40
Phytanic acid1.331.08 × 10−082.871.102.14 × 10−065.35
Capric acid1.744.95 × 10−071.361.691.35 × 10−091.78
Undecanoic Acid1.613.49 × 10−102.441.101.04 × 10−102.75
L-Palmitoylcarnitine13.902.50 × 10−120.299.142.22 × 10−090.70
7-Ketocholesterol1.014.16 × 10−061.511.466.46 × 10−115.45
LysoPE(16:0/0:0)3.854.89 × 10−130.314.144.15 × 10−130.19
25-Hydroxycholesterol2.771.90 × 10−126.031.928.11 × 10−109.34
Undecanedioic acid1.214.85 × 10−070.251.247.43 × 10−110.27
Dihydrotachysterol2.096.82 × 10−100.341.923.47 × 10−080.56
LysoPC(18:0)5.818.00 × 10−090.746.031.86 × 10−100.60
LysoPC(16:0)12.158.81 × 10−120.5113.622.12 × 10−130.26
LysoPE(20:3(8Z,11Z,14Z)/0:0)1.373.84 × 10−060.571.091.89 × 10−100.58
LysoPC(O-18:0)3.872.12 × 10−120.411.551.88 × 10−060.84
LysoPC(18:1(9Z))1.206.82 × 10−31.672.024.62 × 10−052.67
PC(16:0/16:0)2.251.46 × 10−41.293.161.49 × 10−107.42
PC(18:1(9Z)/18:1(9Z))8.553.54 × 10−071.968.543.17 × 10−1326.38
SOPC2.873.36 × 10−21.664.288.73 × 10−1513.75
Stearic acid2.961.77 × 10−071.53.581.32 × 10−112.66
LysoPE(16:0/0:0)4.732.19 × 10−100.414.673.70 × 10−130.37
UDP-d-Glucose4.061.57 × 10−050.181.768.36 × 10−060.46
Pentadecanoic Acid2.022.90 × 10−45.051.113.11 × 10−24.57
Geranyl diphosphate1.862.04 × 10−061.332.493.13 × 10−122.81
EnergyDL-lactate3.034.13 × 10−080.462.365.01 × 10−080.51
Acetoin2.081.25 × 10−060.551.227.97 × 10−050.71
DrugNaproxen1.131.78 × 10−090.121.011.90 × 10−080.20
Promazine1.532.22 × 10−100.062.196.63 × 10−120.14
Desipramine1.853.01 × 10−30.182.622.92 × 10−40.24
Nucleic acidThymidine1.201.34 × 10−090.071.102.59 × 10−090.37
  1. VIP Variable Importance for the Project, FC fold change, SOPC 1-Stearoyl-2-oleoyl-sn-glycerol 3-phosphocholine, UDP-d-Glucose Uridine diphosphate glucose