Table 5 Summary of differential metabolites between OSC and OSC-IC50
Metabolite | 143B | MG63 | |||||
|---|---|---|---|---|---|---|---|
VIP | P value | FC | VIP | P value | FC | ||
Amino acid | Lysyl-Glycine | 2.59 | 1.30 × 10−07 | 0.05 | 2.30 | 5.17 × 10−09 | 0.30 |
Diethanolamine | 1.02 | 7.65 × 10−07 | 0.25 | 3.80 | 5.46 × 10−05 | 0.05 | |
Prolyl-Valine | 2.02 | 1.56 × 10−09 | 0.06 | 1.63 | 6.52 × 10−08 | 0.34 | |
Alanyl-Isoleucine | 1.44 | 5.13 × 10−11 | 0.05 | 1.24 | 1.38 × 10−09 | 0.27 | |
l-Proline | 1.21 | 3.23 × 10−06 | 0.07 | 1.41 | 8.93 × 10−05 | 0.20 | |
L-prolyl-l-phenylalanine | 1.85 | 2.95 × 10−09 | 0.12 | 1.53 | 4.61 × 10−06 | 0.52 | |
Phenylalanyl-Alanine | 7.18 | 4.58 × 10−13 | 0.04 | 6.47 | 3.25 × 10−11 | 0.25 | |
Leucyl-Arginine | 1.09 | 1.98 × 10−09 | 0.1 | 1.56 | 7.75 × 10−09 | 0.16 | |
Isoleucyl-Tyrosine | 2.71 | 6.79 × 10−11 | 0.09 | 2.97 | 3.73 × 10−12 | 0.19 | |
Phenylalanyl-Glutamate | 2.28 | 7.34 × 10−10 | 0.1 | 1.79 | 2.04 × 10−11 | 0.25 | |
S-Methyl-5′-thioadenosine | 1.99 | 3.52 × 10−06 | 1.29 | 1.19 | 8.85 × 10−07 | 1.37 | |
Ornithine | 1.07 | 2.35 × 10−09 | 0.07 | 1.42 | 1.60 × 10−09 | 0.10 | |
Valyl-Tryptophan | 1.85 | 6.98 × 10−07 | 0.05 | 2.62 | 3.05 × 10−12 | 0.06 | |
Alpha-N-Phenylacetyl-l-glutamine | 1.37 | 1.74 × 10−09 | 0.05 | 1.62 | 1.24 × 10−13 | 0.08 | |
Tyrosyl-Serine | 1.56 | 8.97 × 10−10 | 0.08 | 1.35 | 1.11 × 10−12 | 0.20 | |
Phenylalanylphenylalanine | 2.62 | 1.05 × 10−4 | 0.14 | 3.69 | 1.03 × 10−08 | 0.17 | |
Isoleucyl-Tryptophan | 1.78 | 5.36 × 10−4 | 0.12 | 2.72 | 1.02 × 10−07 | 0.10 | |
Phenylalanyl-Tryptophan | 1.59 | 5.23 × 10−13 | 0.06 | 1.24 | 1.35 × 10−05 | 0.39 | |
L-Targinine | 1.70 | 4.56 × 10−06 | 0.04 | 1.43 | 1.90 × 10−06 | 0.05 | |
Methionyl-Valine | 1.14 | 2.71 × 10−05 | 0.12 | 1.03 | 6.06 × 10−05 | 0.18 | |
Valyl-Methionine | 1.72 | 1.38 × 10−10 | 0.03 | 1.84 | 1.56 × 10−09 | 0.04 | |
Lysyl-Threonine | 1.22 | 1.35 × 10−07 | 0.09 | 1.07 | 4.67 × 10-08 | 0.16 | |
Leucyl-Glutamine | 1.09 | 5.00 × 10−07 | 0.1 | 1.99 | 1.60 × 10−08 | 0.02 | |
l-Leucine | 1.33 | 4.13 × 10−05 | 3.28 | 2.05 | 3.10 × 10−07 | 3.22 | |
Pantothenate | 1.56 | 1.64 × 10−05 | 0.67 | 5.04 | 7.40 × 10−11 | 0.26 | |
Glutathione disulfide | 1.41 | 5.28 × 10−05 | 1.23 | 2.37 | 4.21 × 10−13 | 15.32 | |
Harman | 7.91 | 8.60 × 10−12 | 2.44 | 7.02 | 5.15 × 10−14 | 4.09 | |
7,8-Dihydrobiopterin | 1.06 | 5.80 × 10−4 | 0.26 | 2.31 | 7.12 × 10−12 | 0.08 | |
Fatty acid | Erucic acid | 1.55 | 3.44 × 10−07 | 2 | 1.73 | 2.94 × 10−11 | 6.93 |
Erucamide | 13.40 | 1.33 × 10−07 | 2.25 | 14.23 | 4.21 × 10−10 | 9.40 | |
Phytanic acid | 1.33 | 1.08 × 10−08 | 2.87 | 1.10 | 2.14 × 10−06 | 5.35 | |
Capric acid | 1.74 | 4.95 × 10−07 | 1.36 | 1.69 | 1.35 × 10−09 | 1.78 | |
Undecanoic Acid | 1.61 | 3.49 × 10−10 | 2.44 | 1.10 | 1.04 × 10−10 | 2.75 | |
L-Palmitoylcarnitine | 13.90 | 2.50 × 10−12 | 0.29 | 9.14 | 2.22 × 10−09 | 0.70 | |
7-Ketocholesterol | 1.01 | 4.16 × 10−06 | 1.51 | 1.46 | 6.46 × 10−11 | 5.45 | |
LysoPE(16:0/0:0) | 3.85 | 4.89 × 10−13 | 0.31 | 4.14 | 4.15 × 10−13 | 0.19 | |
25-Hydroxycholesterol | 2.77 | 1.90 × 10−12 | 6.03 | 1.92 | 8.11 × 10−10 | 9.34 | |
Undecanedioic acid | 1.21 | 4.85 × 10−07 | 0.25 | 1.24 | 7.43 × 10−11 | 0.27 | |
Dihydrotachysterol | 2.09 | 6.82 × 10−10 | 0.34 | 1.92 | 3.47 × 10−08 | 0.56 | |
LysoPC(18:0) | 5.81 | 8.00 × 10−09 | 0.74 | 6.03 | 1.86 × 10−10 | 0.60 | |
LysoPC(16:0) | 12.15 | 8.81 × 10−12 | 0.51 | 13.62 | 2.12 × 10−13 | 0.26 | |
LysoPE(20:3(8Z,11Z,14Z)/0:0) | 1.37 | 3.84 × 10−06 | 0.57 | 1.09 | 1.89 × 10−10 | 0.58 | |
LysoPC(O-18:0) | 3.87 | 2.12 × 10−12 | 0.41 | 1.55 | 1.88 × 10−06 | 0.84 | |
LysoPC(18:1(9Z)) | 1.20 | 6.82 × 10−3 | 1.67 | 2.02 | 4.62 × 10−05 | 2.67 | |
PC(16:0/16:0) | 2.25 | 1.46 × 10−4 | 1.29 | 3.16 | 1.49 × 10−10 | 7.42 | |
PC(18:1(9Z)/18:1(9Z)) | 8.55 | 3.54 × 10−07 | 1.96 | 8.54 | 3.17 × 10−13 | 26.38 | |
SOPC | 2.87 | 3.36 × 10−2 | 1.66 | 4.28 | 8.73 × 10−15 | 13.75 | |
Stearic acid | 2.96 | 1.77 × 10−07 | 1.5 | 3.58 | 1.32 × 10−11 | 2.66 | |
LysoPE(16:0/0:0) | 4.73 | 2.19 × 10−10 | 0.41 | 4.67 | 3.70 × 10−13 | 0.37 | |
UDP-d-Glucose | 4.06 | 1.57 × 10−05 | 0.18 | 1.76 | 8.36 × 10−06 | 0.46 | |
Pentadecanoic Acid | 2.02 | 2.90 × 10−4 | 5.05 | 1.11 | 3.11 × 10−2 | 4.57 | |
Geranyl diphosphate | 1.86 | 2.04 × 10−06 | 1.33 | 2.49 | 3.13 × 10−12 | 2.81 | |
Energy | DL-lactate | 3.03 | 4.13 × 10−08 | 0.46 | 2.36 | 5.01 × 10−08 | 0.51 |
Acetoin | 2.08 | 1.25 × 10−06 | 0.55 | 1.22 | 7.97 × 10−05 | 0.71 | |
Drug | Naproxen | 1.13 | 1.78 × 10−09 | 0.12 | 1.01 | 1.90 × 10−08 | 0.20 |
Promazine | 1.53 | 2.22 × 10−10 | 0.06 | 2.19 | 6.63 × 10−12 | 0.14 | |
Desipramine | 1.85 | 3.01 × 10−3 | 0.18 | 2.62 | 2.92 × 10−4 | 0.24 | |
Nucleic acid | Thymidine | 1.20 | 1.34 × 10−09 | 0.07 | 1.10 | 2.59 × 10−09 | 0.37 |