Fig. 8

IRLS were efficient in prediction the immunotherapeutic benefit in BLCA. a Violin plots visualized the correlation between IRLS and immune-checkpoint-relevant genes, including CTLA-4, LAG-3, GAL9, PD-1, PD-1LG2, PD-L1, TIM-3 and TIGIT. b The correlation chord chart displayed the mutual correlation between IRLS and immune-checkpoint-relevant genes. c The distribution of immunotherapeutic response in indicated groups stratified by IRLS in TCGA-BLCA cohort based on the TIDE algorithm. Two-sided Fisher’s exact tests were used to analyse contingency tables for ICIs responder. d ROC curves for IRLS in predicting the immunotherapy response in the TCGA-BLCA cohort. e Correlation matrix of IRLS and immune scores, stromal scores and estimate score. f The box plot indicated the correlation between IRLS and immune scores, stromal scores and estimate score