Fig. 8
From: SUV39H1-DNMT3A-mediated epigenetic regulation of Tim-3 and galectin-9 in the cervical cancer
The pathway of SUV39H1 regulated Tim-3 and galectin-9 expression through DNA methylation. a SUV39H1 mediated H3K9 methylation. b The expression level of H3K9me3 increased at the DNMT3A promoter region so that its expression up-regulated. c DNMT3A directly bind to HAVCR2 and LGALS9 promoter regions respectively to increase their methylation level so that their transcriptional activity decreased