Table 2 Univariable and multivariable Cox regression analyses of prognostic factors in stage II CRC patients
Variables | Univariable analyses | Multivariable analyses | ||
|---|---|---|---|---|
HR (95% CI) | p value | HR (95% CI) | p value | |
Gender | 0.291 | |||
Female | Reference | |||
Male | 1.278 (0.811–2.014) | |||
Age | 0.001 | 0.007 | ||
< 60 | Reference | Reference | ||
≥ 60 | 2.254 (1.402–3.623) | 1.615 (1.138–2.292) | ||
Pre-CEA | 0.008 | 0.002 | ||
Negative | Reference | Reference | ||
Positive | 1.795 (1.165–2.764) | 1.678 (1.210–2.325) | ||
Family history | 0.739 | |||
No | Reference | |||
Yes | 1.278 (0.463–3.523) | 0.500 | ||
Unknown | 1.076 (0.369–3.140) | 0.636 | ||
Adjuvant CT | 0.793 | |||
No | Reference | |||
Yes | 1.064 (0.669–1.694) | |||
Tumor site | 0.367 | |||
Left | Reference | |||
Right | 0.901 (0.719–1.130) | |||
T stage | 0.002 | 0.003 | ||
T3 | Reference | Reference | ||
T4a | 1.358 (0.975–1.891) | 0.070 | 1.419 (1.005–2.002) | 0.047 |
T4b | 3.350 (1.619–6.932) | 0.001 | 3.221 (1.532–6.776) | 0.002 |
Histological type | 0.244 | |||
Adenocarcinoma | Reference | |||
Mucinous adenocarcinoma | 1.019 (0.675–1.537) | 0.929 | ||
Signet-ring cell carcinoma | 3.320 (0.819–13.454) | 0.093 | ||
Histological differentiation | 0.002 | 0.009 | ||
Well | Reference | Reference | ||
Moderate | 3.428 (1.570–7.483) | 0.002 | 2.814 (1.274–6.218) | 0.009 |
Poor | 1.965 (0.956–4.037) | 0.066 | 1.619 (0.785–3.342) | 0.192 |
Tumor size | 0.016 | 0.061 | ||
< 4 | Reference | Reference | ||
≥ 4 | 0.675 (0.490–0.931) | 0.721 (0.512–1.015) | ||
LNH | < 0.001 | 0.012 | ||
< 12 | Reference | Reference | ||
≥ 12 | 0.499 (0.353–0.705) | 0.624 (0.432–0.902) | ||
Lymphovascular invasion | 0.053 | |||
Negative | Reference | |||
Positive | 1.539 (0.995–2.380) | |||
Perineural invasion | 0.001 | 0.029 | ||
Negative | Reference | Reference | ||
Positive | 1.868 (1.284–2.717) | 1.557 (1.048–2.315) | ||
CRM | 0.001 | 0.027 | ||
Negative | Reference | Reference | ||
Positive | 3.968 (1.752–8.990) | 2.734 (1.119–6.677) | ||
MMR status | 0.006 | 0.005 | ||
dMMR | Reference | Reference | ||
pMMR | 1.705 (1.165–2.494) | 1.739 (1.184–2.554) | ||
Tumor stage | 0.002 | 0.003 | ||
Stage IIA | Reference | Reference | ||
Stage IIB | 1.358 (0.975–1.891) | 0.070 | 1.419 (1.005–2.002) | 0.047 |
Stage IIC | 3.350 (1.619–6.932) | 0.001 | 3.221 (1.532–6.776) | 0.002 |