Fig. 3From: Potential theranostics of circulating tumor cells and tumor-derived exosomes application in colorectal cancerThe primary tumor distributes CTCs, CSCs, and TDEs in the CRC microenvironment to metastasize and establish secondary tumors in other organs of body via the blood. Exosome derived CTCs release SMAD3, Exosome derived CSCs release CD44v6, CD90, CD105, IL-1B, CXCL 1, 2, 4. In addition, Exosome derived cancer-associated fibroblast released Nf-KB and CD81Back to article page