Fig. 5

Function annotation and enrichment analysis. a Interaction network of 5 candidate snoRNAs and their survival associated mRNAs. The bubble size indicated the –log(pvalue) of univariate cox regression analyses for each mRNA. The top 50 associated mRNAs of each snoRNA were shown. b PPI network of candidate snoRNAs associated prognostic mRNAs. c, d GO and KEGG enrichment analysis of candidate snoRNAs prognostic mRNAs. The bubble size indicated the –log(pvalue) of each GO/KEGG term. e Interaction network of 5 candidate snoRNAs and their associated AS mRNAs. The bubble size indicated the –log(pvalue) of their correlation coefficient. The top50 associated mRNAs of each snoRNA were shown. f PPI network of candidate snoRNAs associated AS mRNAs. g, h GO and KEGG enrichment analysis of candidate snoRNAs associated AS mRNAs. The bubble size indicated the –log(pvalue) of each GO/KEGG term. i The bar plot showed the results of GSVA based on SNORS. The significantly enriched Hallmark gene sets were determined as p value < 0.05 and t value > 1. j Correlation matrix of SNORS, candidate snoRNAs and the relative levels of Hallmark gene sets. The blue indicated positive correlated and yellow indicated negative correlated. The asterisks represented the statistical p value (*p < 0.05; **p < 0.01)