Fig. 4
From: Circ_0000527 promotes the progression of retinoblastoma by regulating miR-646/LRP6 axis
miR-646 functioned as a tumor suppressor in RB. a The expression of miR-646 in 45 cases of paired RB and paracancerous tissues was detected by qRT-PCR. b The expression of miR-646 in retinal pigment epithelial cells (ARPE-19) and RB cells was detected by qRT-PCR. c, d The expression level of miR-646 was detected by qRT-PCR after RB cells were transfected with miR-646 mimics and inhibitors. e RB proliferation was detected by the CCK-8. f Flow cytometry was used to detect apoptosis of RB cells. g, h Transwell assay was used to detect RB cell migration and invasion. ***P < 0.001, and **P < 0.01