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Fig. 6 | Cancer Cell International

Fig. 6

From: Identification of the fatty acid synthase interaction network via iTRAQ-based proteomics indicates the potential molecular mechanisms of liver cancer metastasis

Fig. 6

Effect of FASN knockdown on FSCN1, SIPA1, SPTBN1 and CD59 protein expression in liver cancer. The FASN siRNA significantly downregulated the expression of FASN in HepG2 and SMCC7721 cells and the expression levels of FSCN1, SIPA1, SPTBN1 and CD59 were significantly decreased in response to FASN silencing. The band intensity analysis of protein levels was performed using GAPDH as reference. All the western blot analyses were performed at least three times. *P < 0.05. Values are presented as the mean ± standard deviation. FASN fatty acid synthase, FSCN1 fascin actin-bundling protein 1, SIPA1 signal-induced proliferation-associated 1, SPTBN1 spectrin β, non-erythrocytic 1, siRNA small interfering RNA

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Cancer Cell International

ISSN: 1475-2867

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