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Table 3 Univariate and multivariate analysis of clinical variables and ATP1As for DSS

From: Comprehensive analysis of the expression of sodium/potassium-ATPase α subunits and prognosis of ovarian serous cystadenocarcinoma

Characteristics Univariate analysis Multivariate analysis
Hazard ratio (95% CI) p-value Hazard ratio (95% CI) p-value
FIGO stage (stage I–II vs. stage III–IV) 2.244 (0.922–5.462) 0.075 1.092 (0.257–4.639) 0.905
Histologic grade (G1–2 vs. G3–4) 1.313 (0.833–2.07) 0.24   
Primary therapy outcome (SD-PD vs. PR-CR) 0.299 (0.201–0.443) < 0.001 0.296 (0.169–0.517) < 0.001
Age (< 60 vs. ≥ 60) 1.248 (0.944–1.65) 0.12   
Tumor residual (NRD vs. RD) 2.559 (1.572–4.166) < 0.001 2.991 (1.526–5.86) 0.001
Lymphatic invasion (no vs. yes) 1.407 (0.816–2.425) 0.219   
Venous invasion (no vs. yes) 0.846 (0.45–1.591) 0.604   
Anatomic subdivision (unilateral vs. bilateral) 1.034 (0.747–1.431) 0.841   
TP53 mutation (no vs. yes) 0.643 (0.386–1.07) 0.089 1.026 (0.565–1.861) 0.934
BRCA mutation (no vs. yes) 0.596 (0.313–1.134) 0.115   
ATP1A1 (low vs. high) 1.135 (0.857–1.501) 0.377   
ATP1A2 (low vs. high) 1.304 (0.984–1.727) 0.064 1.413 (0.958–2.085) 0.082
ATP1A3 (low vs. high) 1.572 (1.188–2.081) 0.002 1.723 (1.169–2.54) 0.006
ATP1A4 (low vs. high) 0.721 (0.544–0.956) 0.023 0.611 (0.408–0.916) 0.017