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Fig. 3 | Cancer Cell International

Fig. 3

From: Long non-coding RNA KCNQ1OT1 up-regulates CTNND1 by sponging miR-329-3p to induce the proliferation, migration, invasion, and inhibit apoptosis of colorectal cancer cells

Fig. 3

KCNQ1OT1 targeted miR-329-3p in CRC cells. a Predicted binding sites in KCNQ1OT1 and miR-329-3p were predicted by starBase v2.0. b, c Luciferase activity of SW480 and LS1034 cells was detected by dual-luciferase reporter assay. d The expression levels of miR-329-3p in CRC tissues and corresponding adjacent tissues were examined by qRT-PCR. e The expression level of miR-329-3p in CRC cells (LS1034, SW480) and normal cells (NCM460) was measured by qRT-PCR. f The correlation between miR-329-3p expression and overall survival of CRC patients was analyzed with Kaplan–Meier method. g The correlation between miR-329-3p and KCNQ1OT1 in human CRC samples was analyzed by Spearman’s correlation (P < 0.0001, r = − 0.657). h qRT-PCR was performed to measure miR-329-3p expression after transfected with KCNQ1OT1 or si-KCNQ1OT1 in SW480/LS1034 cells. *P < 0.05, vs. control group

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Cancer Cell International

ISSN: 1475-2867

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