Fig. 3

Interrelated regulatory of CircRNA and EMT. The biological role of circRNA in EMT and major interconnected regulatory networks in esophageal cancer. Several fundamental effectors including Vimentin, Cadherin, Snail and Claudin in this regulatory network. Some circRNAs via interacting with various target genes (including HMGA2, ENAH and AKT2) and β-catenin pathway promote EMT and initiate metastasis