Pathological role of ion channels and transporters in the development and progression of triple-negative breast cancer

Table 1 Summaries of various of ion channels and transporters antagonists experiment in the triple-negative breast cancer

Ion channels and transporters	Transported ions	Alteration in TNBC	Roles in TNBC	Targeted TNBC cell lines	Antagonists
AQP1	Water	Upregulation	Promote proliferation, migration, invasion and induce angiogenesis	CK14 (+) BLBC, 4T1 and MDA-MB-231	Bacopaside I and bacopaside II [32], Ginsenoside Rg3 [33]
AQP3	Water and small solutes	Upregulation	Promote proliferation, invasion migration and increase sensitivity to 5-fluorouracil chemotherapy	MDA-MB-231	CuSO₄ [35]
Calcium modulator 1	Ca²⁺	Upregulation	Promote proliferation, migration, invasion and angiogenesis	MDA-MB-231	Phemindole [78]
NHE1 (SLC9A1)	Na⁺and H⁺	Upregulation	Promote proliferation, migration, invasion and growth, reduce sensitivity to paclitaxel	MDA-MB-231, MDA-MB-468 and Hs578T	Amiloride and cariporide [116], KR-33,028 [118]

ISSN: 1475-2867