Fig. 5
Tan IIA inhibits AML xenograft in vivo. a The tumor volume was detected every 2 days for 4 weeks. The tumor volumes were determined with the following formula: Volume (mm3) = width2 (mm2) × length (mm)/2. *P < 0.05 compared to untreated groups. b The xenograft tumors formed were excised after 4 weeks. The weights of tumors were detected. c RNA was extracted from excised tumors and the expression of miR-497-5p was determined by RT-qPCR. d Total proteins were extracted from excised tumors and the levels of PCNA, cleaved Caspase-3, p-AKT and AKT3 were detected by western blot analysis