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Fig. 4 | Cancer Cell International

Fig. 4

From: A novel mechanism by which ACTA2-AS1 promotes cervical cancer progression: acting as a ceRNA of miR-143-3p to regulate SMAD3 expression

Fig. 4

ACTA2-AS1 could serve as a sponge of miR-143-3p. a Prediction of subcellular localization of ACTA2-AS1 was performed. b miRNA co-expression analysis revealed a high correlation between miR-143-3p and ACTA2-AS1. c The expression of miR-143-3p in RNA sequencing results. d The binding sequence prediction of ACTA2-AS1-wt and construction of ACTA2-AS1-mut sequence. e Luciferase reporter assay demonstrated the miR-143-3p binding site in ACTA2-AS1. f The levels of miR-143-3p in CC tissues were tested. g Spearman’s correlation analysis analyzed the negative relation between ACTA2-AS1 and miR-143-3p in CC tissues. h Expression of miR-143-3p in cervical cancer cell lines was examined using qRT-PCR. ***P < 0.001, **P < 0.01

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Cancer Cell International

ISSN: 1475-2867

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