Fig. 6

Circ_0007841 activates PI3K/AKT signal pathway through targeting miR-338-3p/BRD4 axis. a–c Western blot assay was performed to detect the levels of BRD4 and PI3K/AKT signaling-related proteins in MM cells transfected with si-NC, si-circ_0007841#1, si-circ_0007841#1 + in-miR-NC or si-circ_0007841#1 + in-miR-338-3p, and gray analysis was used to assess the abundance of these proteins. d–f The expression of BRD4 and PI3K/AKT signaling-associated proteins in MM cells transfected with miR-NC, miR-338-3p, miR-338-3p + pcDNA or miR-338-3p + BRD4 was examined by Western blot assay. *P < 0.05, **P < 0.01, ***P < 0.001