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Fig. 1 | Cancer Cell International

Fig. 1

From: LncRNA KCNQ1OT1 sponges miR-15a to promote immune evasion and malignant progression of prostate cancer via up-regulating PD-L1

Fig. 1

KCNQ1OT1, PD-L1 and CD8 were up-regulated, while miR-15a was down-regulated in PC tissues. a–c The expression levels of KCNQ1OT1 (a), miR-15a (b) and PD-L1 (c) were examined by RT-qPCR and compared between 30 pairs of PC tissues and the matching para-tumor normal tissues. d–f The correlations between KCNQ1OT1 and miR-15a (d), between miR-15a and PD-L1 (e), and between KCNQ1OT1 and PD-L1 (f) in PC tissues were examined using Spearman correlation analysis. g CD8 mRNA levels were examined by RT-qPCR and compared between 30 pairs of PC tissues and the matching para-tumor normal tissues. h The correlation between CD8 and PD-L1 in PC tissues was examined using Spearman correlation analysis. i CD8 protein level was examined by IHC. Representative images from PC tissue and the matching normal tissues were shown on the left and quantification of CD8 positive cells on the right. Scale bar: 50 µm. *P < 0.05, **P < 0.01 and ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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