Fig. 1

MiR-145-5p is poorly expressed in GC, while ANGPT2 is highly expressed. a Volcano plot shows the 46 differentially expressed miRNAs in TCGA-STAD dataset; b Differential expression of miR-145-5p in normal and tumor groups in TCGA-STAD samples; c Volcano plot shows the 2760 differentially expressed mRNAs in TCGA-STAD dataset; d Venn diagram is plotted to find the overlapping mRNAs from the differentially expressed mRNAs in TCGA-STAD dataset and the target genes of miR-145-5p predicted in three bioinformatics databases; e Differential expression of ANGPT2 in normal and tumor groups in TCGA-STAD samples; f Overall survival curves of patients in high (red) and low (blue) ANGPT2 expression groups; g, h The expression of miR-145-5p and ANGPT2 mRNA in 5 GC cell lines BGC-823, MGC-803, SGC-7901, HGC-27, AGS and one normal gastric cell line GES-1 is assessed by qRT-PCR; i The protein expression of ANGPT2 in BGC-823 and AGS cell lines; *p < 0.05