Fig. 5

Synergistic effect of ING1b and SIR2 on chemosensitivity of YD-9 and YD-8 cells to cisplatin. Parental YD-9 a or YD-8 b cells, or cells transiently transfected with ING1b expression plasmid, stably transduced with ING1b shRNA, stably transduced with SIR2 shRNA or cells overexpressing ING1b and in which SIR2 has been stably knocked down, were treated with 5 µM of cisplatin and cell viability was measured after indicated times. Same as a and b, but YD-9 cells c or YD-8 cells d were treated with indicated concentrations of cisplatin for 12 h. All data is representative of three independent experiments, each done in triplicate. Error bars, SD. *P < 0.05