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Table 2 Univariate and multivariate Cox regression analysis of clinical-factors/risk-score with overall survival rate in patients

From: A robust 11-genes prognostic model can predict overall survival in bladder cancer patients based on five cohorts

Variables

Univariate analysis

Multivariate analysis

HR (95% CI)

p

HR (95% CI)

p

TCGA-BLCA

 Age

1.04 (1.02–1.06)

1.20E05

1.02 (0.99–1.05)

2.69E−01

 Gender

1.11 (0.78-1.58)

5.56E−01

1.44 (0.81–2.54)

2.14E−01

 Grade

9,608,547.45 (0-Inf)

9.91E−01

5,878,954.98 (0-Inf)

9.96E−01

 Stage

1.81 (1.47-2.23)

2.62E08

0.89 (0.42–1.88)

7.63E−01

 T stage

1.75 (1.37-2.24)

6.57E06

1.38 (0.82–2.34)

2.23E−01

 Node

1.61 (1.35-1.91)

8.06E08

1.44(0.86-2.41)

1.64E−01

 Metastasis

3.06 (1.39-6.73)

5.44E03

0.88(0.28-2.72)

8.24E−01

 Risk score

3.75 (2.43-5.79)

2.46E09

4.1(1.89-8.91)

3.67E04

GSE13507

 Age

1.07 (1.04–1.1)

4.53E08

1.07 (1.04–1.1)

8.71E06

 Gender

1.56 (0.88–2.77)

1.29E−01

1.57 (0.81–3.03)

1.81E−01

 Grade

1.9 (1.49–2.42)

2.46E07

1 (0.54–1.86)

9.97E−01

 Stage

2.74 (1.69–4.43)

4.00E05

1.06 (0.52–2.14)

8.70E−01

 T stage

2.05 (1.64–2.58)

5.06E10

1.51 (0.82–2.79)

1.83E−01

 Node

3.32 (2.23–4.94)

3.88E09

2.21 (1.09–4.46)

2.71E02

 Metastasis

9.9 (4.38–22.37)

3.64E08

3.61 (1.2–10.86)

2.21E02

 Risk score

11.16 (4.22–29.47)

1.14E06

1.33 (0.26–6.87)

7.37E−01

GSE32548

 Age

1.04 (0.99–1.08)

9.34E−02

1.06 (1.01–1.1)

2.00E02

 Gender

0.78 (0.29–2.07)

6.13E−01

0.66 (0.23–1.85)

4.27E−01

 Grade

2.26 (1.07–4.77)

3.26E02

0.46 (0.15–1.44)

1.83E−01

 T stage

3.53 (1.89–6.6)

7.42E05

3.97 (1.58–9.99)

3.41E03

 Risk score

43.5 (6.85–276.49)

6.37E05

12.81 (1.06–154.42)

4.46E02

GSE32894

 Age

0.98 (0.95–1.01)

1.79E−01

0.97 (0.92–1.01)

1.63E−01

 Gender

1.47 (0.55–3.93)

4.45E−01

1.35 (0.49–3.74)

5.61E−01

 Grade

7.59 (2.45–23.52)

4.45E04

3.58 (1.05–12.13)

4.08E02

 T stage

0.98 (0.62–1.56)

9.42E−01

1 (0.58–1.7)

9.86E−01

 Risk score

140.69 (25.35–780.79)

1.54E08

31.03 (3.79–253.97)

1.36E03

  1. Italic font means statistically significant
  2. HR hazard ratio, CI confidence interval, Inf infinity