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Fig. 7 | Cancer Cell International

Fig. 7

From: Development of syngeneic murine cell lines for use in immunocompetent orthotopic lung cancer models

Fig. 7

Validation of an EML4-ALK rearranged cell line. a H&E stain showing orthotopic tumor formation by line Y143. Scale bar is 100 µm and the red line denotes the tumor border. b PCR of genomic DNA demonstrating the 190 bp EML4-ALK rearrangement. Positive control DNA was harvested directly from lung tumors induced by the Ad-EA virus while negative control DNA was harvested from normal mouse lung. c Crizotinib treatment reduces pAKT and pERK in Y143 cells. d Y143 growth can be inhibited in vitro by TAE684 with an IC50 of 22 nM

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