Fig. 3

Somatic insertion of LINE-1 elements in the genome of colorectal advanced adenomas. a The circos plot shows the incidence and location of LINE-1 insertions in six advanced adenoma polyp tissue compared to one normal mucosa. The outer track shows the location of insertions in relation to cytobands of chromosomes. From outside to inside, the second track shows the size and type of insertions (non-reference or reference) (the right guide inset). From outside to inside, the third track shows the genes targeted by insertions and target regions (promoters, introns, and transcription termination regions). The innermost heatmap track shows the incidence of insertion for each genomic region (see the left guide inset). b Length and number of LINE-1 reference, non-reference, and non-reference full-length insertions. c Percentage of LINE-1 insertions in each of the genomic regions