Fig. 2
From: A novel role of Krüppel-like factor 8 as an apoptosis repressor in hepatocellular carcinoma
Knockout of KLF8 changed the H3K27 acetylation genes in HCC cells. a Distribution of DNA fragments obtained by anti-H3K27ac ChIP-seq in KLF8KO-LM3 (up) or LM3 control (down) cells. b Comparison of H3K27ac between KLF8KO-LM3 (left) and LM3 (right) cells. H3K27ac ChIP-seq signals are plotted on center-aligned peaks from either KLF8KO-LM3 or LM3. K-Means cluster is employed to separate peaks with more enrichment in KLF8KO-LM3 and those with more enrichment in LM3. The significant enrichment of H3K27ac upon KLF8 knockout suggests repressive role of KLF8 in gene regulation. c, d GO analysis of H3K27ac genes in KLF8KO-LM3 (c) or LM3 (d) cells. The vertical axis represents the GO category, and the horizontal axis is the log of the P value. e, f KEGG analysis of H3K27ac genes in KLF8KO-LM3 (e) or LM3 (f) cells. The vertical axis is the pathway category, and the horizontal axis represents the log of the P value