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Fig. 6 | Cancer Cell International

Fig. 6

From: RUNX2 interacts with BRG1 to target CD44 for promoting invasion and migration of colorectal cancer cells

Fig. 6

Model of the interaction and relationship among RUNX2, BRG1, CD44, and CRC. RUNX2 synergizes with BRG1 for promoting the CD44 expression as well as for enhancing the EMT process and the invasion and migration of CRC cells. Knockdown of BRG1 with specific si-RNA could markedly inhibit the RUNX2-mediated upregulation of the CD44 expression, suggesting that RUNX2 promotes the CD44 expression and EMT depending on the interaction between RUNX2 and BRG1 in CRC cells

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Cancer Cell International

ISSN: 1475-2867

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