Table 2 The frequencies of driver mutation genes in CccRCC and TCGA datasets
Gene | Frequency in Chinese ccRCC (%) | Frequency in TCGA KIRC white (%) | p-value (Fisher’s exact test) |
|---|---|---|---|
VHL | 76.4 | 52.8 | 0.000862049 |
BAP1 | 18.2 | 9 | 0.053248208 |
NCOR2 | 12.7 | 1.4 | 0.000127079 |
SETD2 | 10.9 | 11 | 1 |
PBRM1 | 9.1 | 33.7 | 8.38E−05 |
ATM | 9.1 | 3.5 | 0.065990135 |
ERBB3 | 9.1 | 1.9 | 0.011804502 |
NBN | 9.1 | 0.4 | 0.000226619 |
DNM2 | 9.1 | 0.2 | 7.06E−05 |
PTEN | 7.3 | 4.3 | 0.299167676 |
KMT2C | 7.3 | 3.8 | 0.269293981 |
GOLGA5 | 7.3 | 1.1 | 0.010440507 |
MTOR | 5.5 | 7.1 | 1 |
FAT1 | 5.5 | 3.5 | 0.449134307 |
PTCH1 | 5.5 | 2.1 | 0.131792795 |
MSH6 | 5.5 | 1.1 | 0.045880562 |
PTPRB | 5.5 | 0.9 | 0.031041033 |
EXT2 | 5.5 | 0.4 | 0.01040418 |
APC | 3.6 | 1.1 | 0.170756605 |
KDR | 3.6 | 1.1 | 0.170756605 |
XPC | 3.6 | 1.1 | 0.170756605 |
TSC1 | 3.6 | 0.9 | 0.13083787 |
FGFR4 | 3.6 | 0.7 | 0.093628013 |
SH2B3 | 3.6 | 0.4 | 0.06033848 |
TGFBR2 | 3.6 | 0.4 | 0.06033848 |
FANCE | 1.8 | 4.3 | 0.711854112 |
PIK3CA | 1.8 | 4 | 0.70899921 |
TP53 | 1.8 | 3.3 | 1 |
POLE | 1.8 | 3.1 | 1 |
CHD4 | 1.8 | 2.6 | 1 |
SMARCA4 | 1.8 | 2.3 | 1 |
ATR | 1.8 | 2.1 | 1 |
CDK12 | 1.8 | 2.1 | 1 |
TET2 | 1.8 | 2.1 | 1 |
CHEK2 | 1.8 | 1.9 | 1 |
EGFR | 1.8 | 1.9 | 1 |
BLM | 1.8 | 1.6 | 0.604409035 |
FLT4 | 1.8 | 1.6 | 0.604409035 |
GNAS | 1.8 | 1.6 | 0.604409035 |
MYH11 | 1.8 | 1.6 | 0.604409035 |
TRRAP | 1.8 | 1.6 | 0.604409035 |
NCOR1 | 1.8 | 1.4 | 0.55540565 |
PIK3CB | 1.8 | 1.4 | 0.55540565 |
FBXW7 | 1.8 | 1.1 | 0.500455786 |
GATA2 | 1.8 | 1.1 | 0.500455786 |
KAT6B | 1.8 | 1.1 | 0.500455786 |
MLLT4 | 1.8 | 1.1 | 0.500455786 |
TCF12 | 1.8 | 1.1 | 0.500455786 |
ERBB2 | 1.8 | 0.9 | 0.4388528 |
ARID1B | 1.8 | 0.9 | 0.4388528 |
ASXL1 | 1.8 | 0.9 | 0.4388528 |
CIC | 1.8 | 0.9 | 0.4388528 |
JAK3 | 1.8 | 0.9 | 0.4388528 |
MECOM | 1.8 | 0.9 | 0.4388528 |
NUP98 | 1.8 | 0.9 | 0.4388528 |
PER1 | 1.8 | 0.9 | 0.4388528 |
BARD1 | 1.8 | 0.7 | 0.369807843 |
DDR2 | 1.8 | 0.7 | 0.369807843 |
MET | 1.8 | 0.7 | 0.369807843 |
NDRG1 | 1.8 | 0.4 | 0.292440502 |
FANCG | 1.8 | 0.4 | 0.292440502 |
PLCG1 | 1.8 | 0.4 | 0.292440502 |
PMS2 | 1.8 | 0.4 | 0.292440502 |
PRF1 | 1.8 | 0.2 | 0.205768403 |
CEBPA | 1.8 | 0.2 | 0.205768403 |
MAP2K1 | 1.8 | 0.2 | 0.205768403 |
MYH9 | 1.8 | 0.2 | 0.205768403 |
PRDM1 | 1.8 | 0.2 | 0.205768403 |
TCF7L2 | 1.8 | 0.2 | 0.205768403 |
FH | 1.8 | 0 | 0.108695652 |
CDKN1B | 1.8 | 0 | 0.108695652 |
KLF6 | 1.8 | 0 | 0.108695652 |
PPM1D | 1.8 | 0 | 0.108695652 |
TRAF7 | 1.8 | 0 | 0.108695652 |
KDM5C | 0.0 | 6.9 | 0.037678184 |
ARID1A | 0.0 | 5.5 | 0.095406442 |
MALAT1 | 0.0 | 2.1 | 0.606792113 |
FGFR3 | 0.0 | 1.4 | 1 |
ABL2 | 0.0 | 1.1 | 1 |
BCL6 | 0.0 | 1.1 | 1 |
CDK4 | 0.0 | 0.9 | 1 |
CDH1 | 0.0 | 0.7 | 1 |
PALB2 | 0.0 | 0.7 | 1 |
FANCF | 0.0 | 0.2 | 1 |