Fig. 6

Schematic representation of the potential molecular mechanisms involved in miR-21 in immunosuppressive ability of MDSCs in lung cancer. In lung cancer, upregulated miR-21 inhibits the expression of downstream target gene RUNX1. Since the expression of YAP was mediated through binding with RUNX1 in the promoter region, so the downregulation of RUNX1 can upregulate the expression of YAP, thus inhibiting the immune resistance of MDSCs and promoting the development of tumors